JVI Accepts, published online ahead of print on 29 August 2007
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J. Virol. doi:10.1128/JVI.00800-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Identification of an arsenic sensitive block to primate lentiviral infection of human dendritic cells

Marjorie Pion, Romaine Stalder, Rafael Correa, Bastien Mangeat, Greg J. Towers, and Vincent Piguet*

Depts. of Dermatology and Venereology, Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, Geneva, Switzerland; MRC Centre for Medical Molecular Virology, Department of Infection, Royal Free and University College Medical School, UCL, London W1T4JF, United Kingdom

* To whom correspondence should be addressed. Email: vincent.piguet{at}medecine.unige.ch.


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Abstract

Dendritic cells are central to the early events of HIV-1 transmission but HIV-1 infects dendritic cells inefficiently in vitro as compared to activated CD4+ T cells. There is a strong post-entry restriction to HIV-1 infection in dendritic cells, partly mediated by the cellular restriction factor APOBEC3G. Here we reveal that arsenic trioxide markedly increases HIV infection of immature and mature dendritic cells as well as blood-derived myeloid dendritic cells, in an APOBEC3G and TRIM5alpha independent way. Our data suggest the presence of powerful, arsenic sensitive antiviral activities in primary human immune cells of the dendritic cell lineage.




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