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J. Virol. doi:10.1128/JVI.00530-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A virus In Vivo

Columbus Children's Research Institute, Columbus, Ohio 43205; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio 43210

^* To whom correspondence should be addressed. Email: durbinj{at}ccri.net.

	Abstract

Type I interferon (IFN) induction is an immediate response to virus infection, and very high levels of these cytokines are produced when the TLRs expressed at high levels by plasmacytoid dendritic cells (pDCs) are triggered by viral nucleic acids. Unlike many RNA viruses, respiratory syncytial virus (RSV) does not appear to activate pDCs through their TLRs, and it is not clear how this difference affects IFN-/ induction in vivo. In this study we compared type I IFN production triggered by RSV or influenza A virus infection of BALB/c mice and found that while both viruses induced IFN-/ production by pDCs in vitro, only influenza virus infection could stimulate type I IFN synthesis by pDCs in vivo. In situ hybridization studies demonstrated that the infected respiratory epithelium was a major source of IFN-/ in response to either infection, but in pDC-depleted animals only type I IFN induction by influenza virus was impaired.

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