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J. Virol. doi:10.1128/JVI.00200-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Establishment of Cottontail Rabbit Papillomavirus/HLA-A2.1 Transgenic Rabbit Model

Jake Gittlen Cancer Research Foundation, Department of Pathology, Department of Microbiology and Immunology, Department of Comparative Medicine, Pennsylvania State University college of medicine, Hershey, PA 17033, USA

^* To whom correspondence should be addressed. Email: ndc1{at}psu.edu.

	Abstract

Three transgenic rabbit lines that express a well-characterized human major histocompatibility complex class I gene (HLA-A2.1) have been established. All three lines carry the HLA-A2.1 heavy chain and are able to pass the transgene to their offspring with both outbred and EIII/JC inbred genetic background. HLA-A2.1 co-localizes with rabbit MHCI exclusively on the cell surface. These HLA-A2.1 transgenic rabbits demonstrated similar infection patterns to CRPV challenge when compared with normal rabbits although higher regression rates were found in HLA-A2.1 transgenic rabbits. Because the CRPV genome can accommodate significant modifications, the CRPV/HLA-A2.1 rabbit model has the potential to be used to screen HLA-A2.1 restricted immunogenic epitopes from human papillomaviruses in the context of in vivo papillomavirus infection.