This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stuller, K. A.
Right arrow Articles by Flaño, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stuller, K. A.
Right arrow Articles by Flaño, E.

 Previous Article  |  Next Article 

Journal of Virology, May 2009, p. 4700-4703, Vol. 83, No. 9
0022-538X/09/$08.00+0     doi:10.1128/JVI.02240-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

CD4 T Cells Mediate Killing during Persistent Gammaherpesvirus 68 Infection {triangledown}

Kathleen A. Stuller1 and Emilio Flaño1,2*

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205,1 College of Medicine, The Ohio State University, Columbus, Ohio 432102

Received 23 October 2008/ Accepted 16 February 2009

CD4 T cells are critical for the control of gammaherpesvirus persistence, but their direct effector mechanisms of virus control in vivo are still poorly understood. In this study, we use murine gammaherpesvirus 68 ({gamma}HV68) in in vitro and in vivo cytotoxicity assays to show CD4-dependent killing of {gamma}HV68-loaded cells in mice persistently infected with {gamma}HV68. Our results underscore the cytotoxic capacity of CD4 T cells during {gamma}HV68 persistence.

* Corresponding author. Mailing address: Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205. Phone: (614) 722-4064. Fax: (614) 722-3680. E-mail: emilio.flano{at}nationwidechildrens.org

{triangledown} Published ahead of print on 25 February 2009.

Journal of Virology, May 2009, p. 4700-4703, Vol. 83, No. 9
0022-538X/09/$08.00+0     doi:10.1128/JVI.02240-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»