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Journal of Virology, May 2009, p. 4695-4699, Vol. 83, No. 9
0022-538X/09/$08.00+0     doi:10.1128/JVI.02241-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Human Cytomegalovirus UL112-113 Locus Can Activate the Full Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Cycle{triangledown}

Richard Wells, Laurence Stensland, and Jeffrey Vieira*

Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109

Received 23 October 2008/ Accepted 3 February 2009

Human cytomegalovirus (HCMV) infection of a cell containing latent Kaposi's sarcoma-associated herpesvirus (KSHV) results in the activation of KSHV lytic replication and the production of infectious virus. In this study, we examined the HCMV genes identified as having a role in the activation of HCMV early genes for their ability to activate KSHV lytic replication. It was found that the UL112-113 locus was able to activate the complete KSHV lytic cycle, while the UL122-123 locus, encoding the IE1 and IE2 proteins, known to be strong transactivators, did not.

* Corresponding author. Mailing address: University of Washington, Dept. of Laboratory Medicine, Box 358070, 1959 NE Pacific St., Seattle, WA 98109. Phone: (206) 732-6107. Fax: (206) 732-6109. E-mail: vieiraj{at}u.washington.edu

{triangledown} Published ahead of print on 11 February 2009.

Journal of Virology, May 2009, p. 4695-4699, Vol. 83, No. 9
0022-538X/09/$08.00+0     doi:10.1128/JVI.02241-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wang, S.-K., Hu, C.-H., Lu, M.-C., Duh, C.-Y., Liao, P.-C., Tyan, Y.-C. (2009). Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus. J. Gen. Virol. 90: 2840-2848 [Abstract] [Full Text]  


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