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Journal of Virology, April 2009, p. 3402-3406, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02122-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evolution of the Sabin Vaccine into Pathogenic Derivatives without Appreciable Changes in Antigenic Properties: Need for Improvement of Current Poliovirus Surveillance{triangledown}

Maria L. Yakovenko,1,{dagger} Ekaterina A. Korotkova,1,{dagger} Olga E. Ivanova,2 Tatyana P. Eremeeva,2 Elena Samoilovich,3 Iryna Uhova,3 Gene V. Gavrilin,4 and Vadim I. Agol1,2*

M. V. Lomonosov Moscow State University, Moscow 119899, Russia,1 M. P. Chumakov Institute of Poliomyelitis & Viral Encephalitides, Russian Academy of Medical Sciences, Moscow Region 142782, Russia,2 Research Institute for Epidemiology and Microbiology, Ministry of Health, Minsk 220114, Belarus,3 Communicable Diseases Unit, Regional Office for Europe, World Health Organization, Copenhagen 2100, Denmark4

Received 8 October 2008/ Accepted 3 January 2009

The Sabin oral polio vaccine (OPV) may evolve into pathogenic viruses, causing sporadic cases and outbreaks of poliomyelitis. Such vaccine-derived polioviruses (VDPV) generally exhibit altered antigenicity. The current paradigm to distinguish VDPV from OPV and wild polioviruses is to characterize primarily those poliovirus isolates that demonstrate deviations from OPV in antigenic and genetic intratypic differentiation (ITD) tests. Here we report on two independent cases of poliomyelitis caused by VDPVs with "Sabin-like" properties in several ITD assays. The results suggest the existence of diverse pathways of OPV evolution and necessitate improvement of poliovirus surveillance, which currently potentially misses this class of VDPV.

* Corresponding author. Mailing address: Institute of Poliomyelitis, Kievskoye Shosse 27 km., Moscow Region 142782, Russia. Phone: 7 (495) 439-9026. Fax: 7 (495) 549-6760. E-mail: agol{at}belozersky.msu.ru

{triangledown} Published ahead of print on 7 January 2009.

{dagger} M.Y.L. and E.A.K. contributed equally to this article.

Journal of Virology, April 2009, p. 3402-3406, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02122-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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