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Journal of Virology, March 2009, p. 2770-2777, Vol. 83, No. 6
0022-538X/09/$08.00+0     doi:10.1128/JVI.01841-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Gag p27-Specific B- and T-Cell Responses in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys{triangledown}

José-Manuel Lozano Reina,1,{dagger},{ddagger} David Favre,2,{ddagger} Zeljka Kasakow,2 Véronique Mayau,1 Marie-Thérèse Nugeyre,1 Thierno Ka,3 Abdourahmane Faye,3 Christopher J. Miller,4 Daniel Scott-Algara,1 Joseph M. McCune,2 Françoise Barré-Sinoussi,1 Ousmane M. Diop,3 and Michaela C. Müller-Trutwin1*

Institut Pasteur, Régulation des Infections Rétrovirales, Paris, France,1 Division of Experimental Medicine, University of California at San Francisco, San Francisco, CA,2 Institut Pasteur, Dakar, Sénégal,3 CNPRC, UC Davis, Davis, CA4

Received 2 September 2008/ Accepted 4 December 2008

Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4+ and CD8+ T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.

* Corresponding author. Mailing address: Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33140613969. Fax: 33145688957. E-mail: michaela.muller-trutwin{at}pasteur.fr

{triangledown} Published ahead of print on 24 December 2008.

{dagger} Present address: Hospital Universitario Reina Sofía, Córdoba, Spain.

{ddagger} J.M.L.R. and D.F. contributed equally to this work.

Journal of Virology, March 2009, p. 2770-2777, Vol. 83, No. 6
0022-538X/09/$08.00+0     doi:10.1128/JVI.01841-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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