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Journal of Virology, March 2009, p. 2397-2403, Vol. 83, No. 5
0022-538X/09/$08.00+0     doi:10.1128/JVI.02189-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Genome Comparison of a Nonpathogenic Myxoma Virus Field Strain with Its Ancestor, the Virulent Lausanne Strain {triangledown} ,{dagger}

Mónica Morales,1,§ Miguel A. Ramírez,1,{ddagger} María J. Cano,1 Mario Párraga,1 Joaquín Castilla,1,|| Luis I. Pérez-Ordoyo,2 Juan M. Torres,1 and Juan Bárcena1*

Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain,1 Departamento de I+D, Laboratorios Syva S. A. Avda, Párroco Pablo Díez, 49-57, 24010 León, Spain2

Received 16 October 2008/ Accepted 4 December 2008

One of the best-studied examples of host-virus coevolution is the release of myxoma virus (MV) for biological control of European rabbits in Australia and Europe. To investigate the genetic basis of MV adaptation to its new host, we sequenced the genome of 6918, an attenuated Spanish field strain, and compared it with that of Lausanne, the strain originally released in Europe in 1952. Although isolated 43 years apart, the genomes were highly conserved (99.95% identical). Only 32 of the 159 MV predicted proteins revealed amino acid changes. Four genes (M009L, M036L, M135R, and M148R) in 6918 were disrupted by frameshift mutations.

* Corresponding author. Mailing address: Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain. Phone: 34 91 620 23 00. Fax: 34 91 620 22 47. E-mail: barcena{at}inia.es

{triangledown} Published ahead of print on 17 December 2008.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

§ Present address: Grupo de Biología y Toxicología Ambiental, Departamento de Física Matemática y de Fluidos, Facultad de Ciencias, Universidad Nacional de Educación a Distancia (UNED), C/ Senda del Rey 9, 28040 Madrid, Spain.

{ddagger} Present address: Departamento de Reproducción Animal, INIA, Ctra, de La Coruña Km 5.9, 28040 Madrid, Spain.

|| Present address: Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458.

Journal of Virology, March 2009, p. 2397-2403, Vol. 83, No. 5
0022-538X/09/$08.00+0     doi:10.1128/JVI.02189-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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