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Journal of Virology, February 2009, p. 2015-2019, Vol. 83, No. 4
0022-538X/09/$08.00+0     doi:10.1128/JVI.02047-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Population Dynamics and Rates of Molecular Evolution of a Recently Emerged Paramyxovirus, Avian Metapneumovirus Subtype C{triangledown} ,{dagger}

Abinash Padhi1 and Mary Poss1,2*

Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802,1 Fogarty International Center, National Institutes of Health, Bethesda, Maryland 208922

Received 28 September 2008/ Accepted 24 November 2008

We report the existence of two distinct sublineages of avian metapneumovirus (MPV) subtype C, a virus which has caused serious economic loss in commercial turkey farms in the United States. This subtype is closely related to human MPV, infects multiple avian species, and is globally distributed. The evolutionary rates of this virus are estimated to be 1.3 x 10–3 to 7 x 10–3 substitutions per site per year, and coalescent estimates place its emergence between 1991 and 1996. The four genes examined show a concordant demographic pattern which is characterized by a rapid increase in population size followed by stable population grown until the present.

* Corresponding author. Mailing address: 208 Mueller Lab, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802. Phone: (814) 867-1213. Fax: (814) 867-2249. E-mail: mposs{at}bx.psu.edu

{triangledown} Published ahead of print on 3 December 2008.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

Journal of Virology, February 2009, p. 2015-2019, Vol. 83, No. 4
0022-538X/09/$08.00+0     doi:10.1128/JVI.02047-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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