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Journal of Virology, July 2009, p. 6798-6805, Vol. 83, No. 13
0022-538X/09/$08.00+0     doi:10.1128/JVI.00256-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection {triangledown}

Galit Alter,1* Suzannah Rihn,1 Katharine Walter,1 Anne Nolting,1 Maureen Martin,2,{dagger} Eric S. Rosenberg,1 Jeffrey S. Miller,3 Mary Carrington,2,{dagger} and Marcus Altfeld1

Ragon Institute of MGH, MIT, and Harvard; Infectious Disease Unit, Massachusetts General Hospital; and Division of AIDS, Harvard Medical School, Boston, Massachusetts,1 Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, Frederick, Maryland,2 Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota3

Received 5 February 2009/ Accepted 13 April 2009

NK cells are critical in the early containment of viral infections. Epidemiological and functional studies have shown an important role of NK cells expressing specific killer immunoglobulin-like receptors (KIRs) in the control of human immunodeficiency virus type 1 (HIV-1) infection, but little is known about the mechanisms that determine the expansion of these antiviral NK cell populations during acute HIV-1 infection. Here we demonstrate that NK cells expressing the activating receptor KIR3DS1+ and, to a lesser extent, the inhibitory receptor KIR3DL1+ specifically expand in acute HIV-1 infection in the presence of HLA-B Bw480I, the putative HLA class I ligand for KIR3DL1/3DS1. These data demonstrate for the first time the HLA class I subtype-dependent expansion of specific KIR+ NK cells during an acute viral infection in humans.

* Corresponding author. Mailing address: Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129. Phone: (617) 724-0546. Fax: (617) 726-5411. E-mail: galter{at}partners.org

{triangledown} Published ahead of print on 22 April 2009.

{dagger} Present address: Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD.

Journal of Virology, July 2009, p. 6798-6805, Vol. 83, No. 13
0022-538X/09/$08.00+0     doi:10.1128/JVI.00256-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lee, S.-H., Kim, K.-S., Fodil-Cornu, N., Vidal, S. M., Biron, C. A. (2009). Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection. JEM 206: 2235-2251 [Abstract] [Full Text]  


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