This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duval, M.
Right arrow Articles by Cavacini, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duval, M.
Right arrow Articles by Cavacini, L. A.

 Previous Article  |  Next Article 

Journal of Virology, May 2008, p. 4671-4674, Vol. 82, No. 9
0022-538X/08/$08.00+0     doi:10.1128/JVI.02499-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

A Bispecific Antibody Composed of a Nonneutralizing Antibody to the gp41 Immunodominant Region and an Anti-CD89 Antibody Directs Broad Human Immunodeficiency Virus Destruction by Neutrophils{triangledown}

Mark Duval, Marshall R. Posner, and Lisa A. Cavacini*

Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215

Received 21 November 2007/ Accepted 4 February 2008

In addition to the direct neutralization of virus, there is a broader potential for antibody-mediated inhibition of human immunodeficiency virus (HIV) by targeting HIV to effector cells. We demonstrate here that a bispecific antibody incorporating a broadly reactive anti-gp41 antibody, F240, and an anti-IgA receptor (CD89) antibody is effective at directing neutrophils to destroy HIV. Not only are neutrophils the predominant type of white blood cells and very efficient at mediating cell cytotoxicity, they are relatively resistant to infection with HIV. Therefore, they represent a significant weapon against infection if they can be directed and armed to destroy HIV and infected cells.

* Corresponding author. Mailing address: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, BL556, Boston, MA 02215. Phone: (617) 632-1161. Fax: (617) 632-0181. E-mail: lcavacin{at}bidmc.harvard.edu

{triangledown} Published ahead of print on 13 February 2008.

Journal of Virology, May 2008, p. 4671-4674, Vol. 82, No. 9
0022-538X/08/$08.00+0     doi:10.1128/JVI.02499-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»