This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davis, M. P.
Right arrow Articles by Tuthill, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davis, M. P.
Right arrow Articles by Tuthill, T. J.

 Previous Article  |  Next Article 

Journal of Virology, April 2008, p. 4169-4174, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.01070-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Recombinant VP4 of Human Rhinovirus Induces Permeability in Model Membranes{triangledown}

Matthew P. Davis,1,{dagger} Graham Bottley,1 Lucy P. Beales,2 Richard A. Killington,1 David J. Rowlands,1 and Tobias J. Tuthill1*

Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom,1 iQur Ltd., Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom2

Received 17 May 2007/ Accepted 21 January 2008

In common with all nonenveloped viruses, the mechanism of picornavirus membrane penetration during cell entry is poorly understood. The small, myristylated capsid protein VP4 has been implicated in this process. Here we show that recombinant VP4 of human rhinovirus 16 has the ability to associate with and induce membrane permeability in otherwise intact liposomes. This provides further evidence that VP4 plays a key role in picornavirus cell entry.

* Corresponding author. Mailing address: Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 113 3435643. Fax: 44 113 3435638. E-mail: t.tuthill{at}leeds.ac.uk

{triangledown} Published ahead of print on 6 February 2008.

{dagger} Present address: Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom.

Journal of Virology, April 2008, p. 4169-4174, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.01070-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Konecsni, T., Berka, U., Pickl-Herk, A., Bilek, G., Khan, A. G., Gajdzig, L., Fuchs, R., Blaas, D. (2009). Low pH-Triggered Beta-Propeller Switch of the Low-Density Lipoprotein Receptor Assists Rhinovirus Infection. J. Virol. 83: 10922-10930 [Abstract] [Full Text]  
  • Goodwin, S., Tuthill, T. J., Arias, A., Killington, R. A., Rowlands, D. J. (2009). Foot-and-Mouth Disease Virus Assembly: Processing of Recombinant Capsid Precursor by Exogenous Protease Induces Self-Assembly of Pentamers In Vitro in a Myristoylation-Dependent Manner. J. Virol. 83: 11275-11282 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»