This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weiler, A. M.
Right arrow Articles by Rakasz, E. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weiler, A. M.
Right arrow Articles by Rakasz, E. G.

 Previous Article  |  Next Article 

Journal of Virology, April 2008, p. 4154-4158, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.01947-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genital Ulcers Facilitate Rapid Viral Entry and Dissemination following Intravaginal Inoculation with Cell-Associated Simian Immunodeficiency Virus SIVmac239{triangledown}

Andrea M. Weiler,1,{dagger} Qingsheng Li,2,{dagger} Lijie Duan,2 Masahiko Kaizu,1 Kim L. Weisgrau,3 Thomas C. Friedrich,1 Matthew R. Reynolds,1 Ashley T. Haase,2 and Eva G. Rakasz1,3*

AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711,1 Department of Microbiology, University of Minnesota—Twin Cities, Minneapolis, Minnesota 55455,2 Immunogenetics and Virology Unit, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 537113

Received 5 September 2007/ Accepted 5 February 2008

Here we report the results of studies in the simian immunodeficiency virus (SIV)-rhesus macaque model of intravaginal transmission of human immunodeficiency virus type 1 in the setting of genital ulcerative diseases. We document preferential association of vRNA with induced ulcers during the first days of infection and show that allogeneic cells of the inoculum traffic from the vaginal lumen to lymphatic tissues. This surprisingly rapid systemic dissemination in this cell-associated SIV challenge model thus reveals the challenges of preventing transmission in the setting of genital ulcerative diseases and illustrates the utility of this animal model in tests of strategies aimed at reducing transmission under these conditions.

* Corresponding author. Mailing address: AIDS Vaccine Laboratory, WNPRC, 555 Science Dr., Madison, WI 53711. Phone: (608) 265-8998. Fax: (608) 265-8084. E-mail: erakasz{at}primate.wisc.edu

{triangledown} Published ahead of print on 13 February 2008.

{dagger} Andrea M. Weiler and Qingsheng Li contributed equally to this study.

Journal of Virology, April 2008, p. 4154-4158, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.01947-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Parikh, U. M., Dobard, C., Sharma, S., Cong, M.-e., Jia, H., Martin, A., Pau, C.-P., Hanson, D. L., Guenthner, P., Smith, J., Kersh, E., Garcia-Lerma, J. G., Novembre, F. J., Otten, R., Folks, T., Heneine, W. (2009). Complete Protection from Repeated Vaginal Simian-Human Immunodeficiency Virus Exposures in Macaques by a Topical Gel Containing Tenofovir Alone or with Emtricitabine. J. Virol. 83: 10358-10365 [Abstract] [Full Text]  
  • Abrahams, M.-R., Anderson, J. A., Giorgi, E. E., Seoighe, C., Mlisana, K., Ping, L.-H., Athreya, G. S., Treurnicht, F. K., Keele, B. F., Wood, N., Salazar-Gonzalez, J. F., Bhattacharya, T., Chu, H., Hoffman, I., Galvin, S., Mapanje, C., Kazembe, P., Thebus, R., Fiscus, S., Hide, W., Cohen, M. S., Karim, S. A., Haynes, B. F., Shaw, G. M., Hahn, B. H., Korber, B. T., Swanstrom, R., Williamson, C., for the CAPRISA Acute Infection Study Team and the, (2009). Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants. J. Virol. 83: 3556-3567 [Abstract] [Full Text]  
  • Gasper-Smith, N., Crossman, D. M., Whitesides, J. F., Mensali, N., Ottinger, J. S., Plonk, S. G., Moody, M. A., Ferrari, G., Weinhold, K. J., Miller, S. E., Reich, C. F. III, Qin, L., Self, S. G., Shaw, G. M., Denny, T. N., Jones, L. E., Pisetsky, D. S., Haynes, B. F. (2008). Induction of Plasma (TRAIL), TNFR-2, Fas Ligand, and Plasma Microparticles after Human Immunodeficiency Virus Type 1 (HIV-1) Transmission: Implications for HIV-1 Vaccine Design. J. Virol. 82: 7700-7710 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»