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Journal of Virology, March 2008, p. 3135-3138, Vol. 82, No. 6
0022-538X/08/$08.00+0     doi:10.1128/JVI.01727-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Differential Requirements for T Cells in Viruslike Particle- and Rotavirus-Induced Protective Immunity{triangledown}

Sarah E. Blutt,1,2 Kelly L. Warfield,1,{dagger} Mary K. Estes,1 and Margaret E. Conner1,2*

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030F,1 Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas 770302

Received 8 August 2007/ Accepted 19 December 2007

Correlates of protection from rotavirus infection are controversial. We compared the roles of B and T lymphocytes in protective immunity induced either by intranasally administered nonreplicating viruslike particles or inactivated virus or by orally administered murine rotavirus. We found that protection induced by nonreplicating vaccines requires CD4+ T cells and CD40/CD40L. In contrast, T cells were not required for short-term protective immunity induced by infection, but both T-cell-dependent and -independent mechanisms contributed to long-term maintenance of protection. Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered.

* Corresponding author. Mailing address: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: (713) 798-3590. Fax: (713) 798-3586. E-mail: mconner{at}bcm.edu

{triangledown} Published ahead of print on 9 January 2008.

{dagger} Present address: United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702.

Journal of Virology, March 2008, p. 3135-3138, Vol. 82, No. 6
0022-538X/08/$08.00+0     doi:10.1128/JVI.01727-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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