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Journal of Virology, February 2008, p. 1615-1621, Vol. 82, No. 3
0022-538X/08/$08.00+0     doi:10.1128/JVI.01757-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Macrophage-Derived Simian Immunodeficiency Virus Exhibits Enhanced Infectivity by Comparison with T-Cell-Derived Virus{triangledown}

Peter J. Gaskill,1 Michelle Zandonatti,1 Tim Gilmartin,2 Steven R. Head,2 and Howard S. Fox1*

Molecular and Integrative Neurosciences Department,1 DNA Microarray Core Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 920372

Received 10 August 2007/ Accepted 13 November 2007

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.

* Corresponding author. Mailing address: The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2030, La Jolla, CA 92037. Phone: (858) 784-7171. Fax: (858) 784-7296. E-mail: hsfox{at}scripps.edu

{triangledown} Published ahead of print on 28 November 2007.

Journal of Virology, February 2008, p. 1615-1621, Vol. 82, No. 3
0022-538X/08/$08.00+0     doi:10.1128/JVI.01757-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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