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Journal of Virology, December 2008, p. 12589-12590, Vol. 82, No. 24
0022-538X/08/$08.00+0     doi:10.1128/JVI.01394-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

A Linear Relationship between Fitness and the Logarithm of the Critical Bottleneck Size in Vesicular Stomatitis Virus Populations{triangledown} ,§

Isabel S. Novella,1* Ranendra N. Dutta,1 and Claus O. Wilke2

Department of Medical Microbiology and Immunology, College of Medicine, University of Toledo Health Science Campus, Toledo, Ohio 43614,1 Center for Computational Biology and Bioinformatics, Section of Integrative Biology, and Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Texas 787122

Received 3 July 2008/ Accepted 18 September 2008

We explored the relationship between fitness change and population size during transmission in vesicular stomatitis populations of very high fitness. The results show a linear correlation between the logarithm of the critical bottleneck size (population size at which there are no significant fitness changes after 20 passages) and the initial fitness of the population. In addition, limits to fitness increases during large-population passages of very-high-fitness strains were abolished by increasing the population size during transmission, indicating that beneficial variation is still available in these populations.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Toledo Health Science Campus, Mail stop 1210, Toledo, OH 43614. Phone: (419) 383-6442. Fax: (419) 383-4221. E-mail: isabel.novella{at}utoledo.edu

{triangledown} Published ahead of print on 1 October 2008.

§ Supplemental material for this article may be found at http://jvi.asm.org/.

Journal of Virology, December 2008, p. 12589-12590, Vol. 82, No. 24
0022-538X/08/$08.00+0     doi:10.1128/JVI.01394-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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