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Journal of Virology, October 2008, p. 9928-9936, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.01017-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus Type 1 Replication and Regulation of APOBEC3G by Peptidyl Prolyl Isomerase Pin1{triangledown}

Koichi Watashi,1 Mohammad Khan,2 Venkat R. K. Yedavalli,1 Man Lung Yeung,1 Klaus Strebel,2 and Kuan-Teh Jeang1*

Molecular Virology Section,1 Viral Biochemistry Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208922

Received 15 May 2008/ Accepted 31 July 2008

APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency virus type 1 (HIV-1) replication. HIV-1 synthesizes a viral infectivity factor (Vif) to counter A3G restriction. Currently, it is poorly understood how A3G expression/activity is regulated by cellular factors. Here, we show that the prolyl isomerase Pin1 protein modulates A3G expression. Pin1 was found to be an A3G-interacting protein that reduces A3G expression and its incorporation into HIV-1 virion, thereby limiting A3G-mediated restriction of HIV-1. Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to moderate A3G activity. These new findings suggest a potential Vif-independent way for HIV-1 to moderate the cellular action of A3G.

* Corresponding author. Mailing address: 9000 Rockville Pike, Building 4, Room 306, Bethesda, MD 20892. Phone: (301) 496-6680. Fax: (301) 480-3686. E-mail: kj7e{at}nih.gov

{triangledown} Published ahead of print on 6 August 2008.

Journal of Virology, October 2008, p. 9928-9936, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.01017-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Peloponese, J.-M. Jr., Yasunaga, J., Kinjo, T., Watashi, K., Jeang, K.-T. (2009). Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-{kappa}B. J. Virol. 83: 3238-3248 [Abstract] [Full Text]  
  • Goila-Gaur, R., Khan, M. A., Miyagi, E., Strebel, K. (2009). Differential Sensitivity of "Old" versus "New" APOBEC3G to Human Immunodeficiency Virus Type 1 Vif. J. Virol. 83: 1156-1160 [Abstract] [Full Text]  


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