This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, M.
Right arrow Articles by Wang, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, M.
Right arrow Articles by Wang, H.

 Previous Article  |  Next Article 

Journal of Virology, October 2008, p. 9800-9804, Vol. 82, No. 19
0022-538X/08/$08.00+0     doi:10.1128/JVI.00759-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The F-Like Protein Ac23 Enhances the Infectivity of the Budded Virus of gp64-Null Autographa californica Multinucleocapsid Nucleopolyhedrovirus Pseudotyped with Baculovirus Envelope Fusion Protein F{triangledown} ,{dagger}

Manli Wang,1,3,{ddagger} Ying Tan,1,3,{ddagger} Feifei Yin,1,3 Fei Deng,1 Just M. Vlak,2 Zhihong Hu,1 and Hualin Wang1*

State Key Laboratory of Virology and Joint Laboratory of Invertebrate Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China,1 Laboratory of Virology, Wageningen University, 6709 PD Wageningen, The Netherlands,2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China3

Received 7 April 2008/ Accepted 16 July 2008

The GP64 and F proteins were previously identified as the sole functional envelope fusion proteins in Baculoviridae. F-like proteins, present only in group I nucleopolyhedroviruses (NPVs), are remnant, nonfunctional F proteins. In this report, we describe the effect of the presence or absence of the F-like protein Ac23 in a gp64-null Autographa californica multinucleocapsid NPV pseudotyped with the F protein from Spodoptera exigua multicapsid NPV (SeF). We found that the presence of Ac23 elevates the infectivity of the pseudotyped virus. This is in contrast to the results of Lung et al. (J. Virol. 76:5729-5736, 2002), who found no such effect. The possible reasons for the differing results are discussed.

* Corresponding author. Mailing address: Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China. Phone and fax: 86-27-87199353. E-mail: h.wang{at}wh.iov.cn

{triangledown} Published ahead of print on 23 July 2008.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

{ddagger} M. Wang and Y. Tan contributed equally to this work.

Journal of Virology, October 2008, p. 9800-9804, Vol. 82, No. 19
0022-538X/08/$08.00+0     doi:10.1128/JVI.00759-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yu, I.-L., Bray, D., Lin, Y.-C., Lung, O. (2009). Autographa californica multiple nucleopolyhedrovirus ORF 23 null mutant produces occlusion-derived virions with fewer nucleocapsids. J. Gen. Virol. 90: 1499-1504 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»