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Journal of Virology, October 2008, p. 9546-9554, Vol. 82, No. 19
0022-538X/08/$08.00+0     doi:10.1128/JVI.00895-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Structure of Flexible Filamentous Plant Viruses {triangledown}

Amy Kendall,1 Michele McDonald,1 Wen Bian,1 Timothy Bowles,1 Sarah C. Baumgarten,1 Jian Shi,2,{dagger} Phoebe L. Stewart,2 Esther Bullitt,3 David Gore,4 Thomas C. Irving,4 Wendy M. Havens,5 Said A. Ghabrial,5 Joseph S. Wall,6 and Gerald Stubbs1*

Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37235,1 Department of Molecular Physiology and Biophysics and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232,2 Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118,3 BioCAT, CSRRI, and BCPS, Illinois Institute of Technology, Chicago, Illinois 60439,4 Plant Pathology Department, University of Kentucky, Lexington, Kentucky 40546,5 Biology Department, Brookhaven National Laboratory, Upton, New York 119736

Received 29 April 2008/ Accepted 17 July 2008

Flexible filamentous viruses make up a large fraction of the known plant viruses, but in comparison with those of other viruses, very little is known about their structures. We have used fiber diffraction, cryo-electron microscopy, and scanning transmission electron microscopy to determine the symmetry of a potyvirus, soybean mosaic virus; to confirm the symmetry of a potexvirus, potato virus X; and to determine the low-resolution structures of both viruses. We conclude that these viruses and, by implication, most or all flexible filamentous plant viruses share a common coat protein fold and helical symmetry, with slightly less than 9 subunits per helical turn.

* Corresponding author. Mailing address: Department of Biological Sciences, Vanderbilt University, Box 351634, Station B, Nashville, TN 37235. Phone: (615) 322-2018. Fax: (615) 343-6707. E-mail: gerald.stubbs{at}vanderbilt.edu

{triangledown} Published ahead of print on 30 July 2008.

{dagger} Present address: Division of Biology, California Institute of Technology, Pasadena, CA.

Journal of Virology, October 2008, p. 9546-9554, Vol. 82, No. 19
0022-538X/08/$08.00+0     doi:10.1128/JVI.00895-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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