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Journal of Virology, September 2008, p. 8933-8936, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.02440-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Temporary Depletion of CD11c+ Dendritic Cells Delays Lymphoinvasion after Intraperitonal Scrapie Infection{triangledown}

Sevda Cordier-Dirikoc and Joëlle Chabry*

Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, 660 Route des Lucioles, 06560 Valbonne, France

Received 13 November 2007/ Accepted 12 June 2008

The involvement of immune cells in prion capture and transport to lymphoid tissues still remains unclear. To investigate the role of dendritic cells (DC), we used DTR+/+ mice, a transgenic model designed to trigger short-term ablation of DC. Transient depletion of DC around the time of intraperitoneal infection delayed prion replication in the spleen, as followed by PrPsc amount, a specific hallmark of prion diseases. Consequently, neuroinvasion and incubation time of prion disease were delayed. In contrast, no differences were observed after oral infection. These results suggest that DC act as vectors for prions from the peripheral entry site to the spleen.

* Corresponding author. Mailing address: Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, 660 Route des Lucioles, 06560 Valbonne, France. Phone: 33493957767. Fax: 33493957708. E-mail: chabry{at}ipmc.cnrs.fr

{triangledown} Published ahead of print on 25 June 2008.

Journal of Virology, September 2008, p. 8933-8936, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.02440-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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