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Journal of Virology, September 2008, p. 8927-8932, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00239-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Impact of Exogenous Sequences on the Characteristics of an Epidemic Type 2 Recombinant Vaccine-Derived Poliovirus{triangledown}

Franck B. Riquet,1 Claire Blanchard,1 Sophie Jegouic,1 Jean Balanant,1 Sophie Guillot,1 Marie-Anne Vibet,2 Mala Rakoto-Andrianarivelo,3 and Francis Delpeyroux1*

Unité de Biologie des Virus Entériques,1 Unité de Pharmacoépidémiologie et Maladies Infectieuses, Institut Pasteur, Paris, France,2 Unité de Virologie Médicale, Institut Pasteur de Madagascar, Antananarivo, Madagascar3

Received 2 February 2008/ Accepted 9 June 2008

Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.

* Corresponding author. Mailing address: Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris, Cedex 15, France. Phone: (33) 1 40 61 33 22. Fax: (33) 1 45 68 87 80. E-mail: francis.delpeyroux{at}pasteur.fr

{triangledown} Published ahead of print on 25 June 2008.

Journal of Virology, September 2008, p. 8927-8932, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00239-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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