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Journal of Virology, September 2008, p. 8849-8862, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00553-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evidence for a Structural Relationship between BRCT Domains and the Helicase Domains of the Replication Initiators Encoded by the Polyomaviridae and Papillomaviridae Families of DNA Tumor Viruses{triangledown} ,{dagger}

Anuradha Kumar,{ddagger} Woo S. Joo,{ddagger},§ Gretchen Meinke,{ddagger} Stephanie Moine, Elena N. Naumova, and Peter A. Bullock*

Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111

Received 12 March 2008/ Accepted 19 June 2008

Studies of DNA tumor viruses have provided important insights into fundamental cellular processes and oncogenic transformation. They have revealed, for example, that upon expression of virally encoded proteins, cellular pathways involved in DNA repair and cell cycle control are disrupted. Herein, evidence is presented that BRCT-related regions are present in the helicase domains of the viral initiators encoded by the Polyomaviridae and Papillomaviridae viral families. Of interest, BRCT domains in cellular proteins recruit factors involved in diverse pathways, including DNA repair and the regulation of cell cycle progression. Therefore, the viral BRCT-related regions may compete with host BRCT domains for particular cellular ligands, a process that would help to explain the pleiotropic effects associated with infections with many DNA tumor viruses.

* Corresponding author. Mailing address: Department of Biochemistry A703, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-0447. Fax: (617) 636-2409. E-mail: Peter.Bullock{at}tufts.edu

{triangledown} Published ahead of print on 25 June 2008.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

{ddagger} The first three authors contributed equally to this work.

§ Present address: Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111.

Present address: Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

Journal of Virology, September 2008, p. 8849-8862, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00553-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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