This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakatsu, Y.
Right arrow Articles by Yanagi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakatsu, Y.
Right arrow Articles by Yanagi, Y.

 Previous Article  |  Next Article 

Journal of Virology, September 2008, p. 8296-8306, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00108-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Measles Virus Circumvents the Host Interferon Response by Different Actions of the C and V Proteins{triangledown}

Yuichiro Nakatsu, Makoto Takeda,* Shinji Ohno, Yuta Shirogane, Masaharu Iwasaki, and Yusuke Yanagi

Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Received 15 January 2008/ Accepted 6 June 2008

Measles is an acute febrile infectious disease with high morbidity and mortality. The genome of measles virus (MV), the causative agent, encodes two accessory products, V and C proteins, that play important roles in MV virulence. The V but not the C protein of the IC-B strain (a well-characterized virulent strain of MV) has been shown to block the Jak/Stat signaling pathway and counteract the cellular interferon (IFN) response. We have recently shown that a recombinant IC-B strain that lacks C protein expression replicates poorly in certain cell lines, and its growth defect is related to translational inhibition and strong IFN induction. Here, we show that the V protein of the MV IC-B strain also blocks the IFN induction pathway mediated by the melanoma differentiation-associated gene 5 product, thus actively interfering with the host IFN response at two different steps. On the other hand, the C protein per se possesses no activity to block the IFN induction pathway. Our data indicate that the C protein acts as a regulator of viral RNA synthesis, thereby acting indirectly to suppress IFN induction. Since recombinant MVs with C protein defective in modulating viral RNA synthesis or lacking C protein expression strongly stimulate IFN production, in spite of V protein production, both the C and V proteins must be required for MV to fully circumvent the host IFN response.

* Corresponding author. Mailing address: Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan. Phone: 81 92 642 6138. Fax: 81 92 642 6140. E-mail: mtakeda{at}virology.med.kyushu-u.ac.jp

{triangledown} Published ahead of print on 18 June 2008.

Journal of Virology, September 2008, p. 8296-8306, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00108-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nakatsu, Y., Takeda, M., Iwasaki, M., Yanagi, Y. (2009). A Highly Attenuated Measles Virus Vaccine Strain Encodes a Fully Functional C Protein. J. Virol. 83: 11996-12001 [Abstract] [Full Text]  
  • Young, D. F., Galiano, M. C., Lemon, K., Chen, Y.-H., Andrejeva, J., Duprex, W. P., Rima, B. K., Randall, R. E. (2009). Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist. J. Gen. Virol. 90: 2731-2738 [Abstract] [Full Text]  
  • Iwasaki, M., Takeda, M., Shirogane, Y., Nakatsu, Y., Nakamura, T., Yanagi, Y. (2009). The Matrix Protein of Measles Virus Regulates Viral RNA Synthesis and Assembly by Interacting with the Nucleocapsid Protein. J. Virol. 83: 10374-10383 [Abstract] [Full Text]  
  • Lo, M. K., Harcourt, B. H., Mungall, B. A., Tamin, A., Peeples, M. E., Bellini, W. J., Rota, P. A. (2009). Determination of the henipavirus phosphoprotein gene mRNA editing frequencies and detection of the C, V and W proteins of Nipah virus in virus-infected cells. J. Gen. Virol. 90: 398-404 [Abstract] [Full Text]  
  • Toth, A. M., Devaux, P., Cattaneo, R., Samuel, C. E. (2009). Protein Kinase PKR Mediates the Apoptosis Induction and Growth Restriction Phenotypes of C Protein-Deficient Measles Virus. J. Virol. 83: 961-968 [Abstract] [Full Text]  
  • Takeda, M., Ohno, S., Tahara, M., Takeuchi, H., Shirogane, Y., Ohmura, H., Nakamura, T., Yanagi, Y. (2008). Measles Viruses Possessing the Polymerase Protein Genes of the Edmonston Vaccine Strain Exhibit Attenuated Gene Expression and Growth in Cultured Cells and SLAM Knock-In Mice. J. Virol. 82: 11979-11984 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»