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Journal of Virology, July 2008, p. 6767-6771, Vol. 82, No. 13
0022-538X/08/$08.00+0     doi:10.1128/JVI.02550-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Virus-Specific Interleukin-17-Producing CD4+ T Cells Are Detectable in Early Human Immunodeficiency Virus Type 1 Infection {triangledown}

Feng Yun Yue,1 Asad Merchant,1 Colin M. Kovacs,2 Mona Loutfy,2 Desmond Persad,2 and Mario A. Ostrowski1,3*

Clinical Sciences Division, University of Toronto, Toronto, Canada,1 St. Michael's Hospital, University of Toronto, Toronto, Canada,3 CIRC (Canadian Immunodeficiency Research Collaborative), Toronto, Canada2

Received 28 November 2007/ Accepted 11 April 2008

TH-17 cells have been shown to play a role in bacterial defense, acute inflammation, and autoimmunity. We examined the role of interleukin 17 (IL-17) production in human immunodeficiency virus type 1 (HIV-1) infection. Both HIV-1- and cytomegalovirus (CMV)-specific IL-17-producing CD4+ T cells were detectable in early HIV-1 infection but were reduced to nondetectable levels in chronic and nonprogressive HIV-1 infection. IL-17-producing CMV-specific cells were not detected in blood from HIV-1-uninfected normal volunteers. Virus-specific TH-17 cells could coexpress other cytokines and could express CCR4 or CXCR3. Although the etiology of these cells has yet to be established, we propose that microbial translocation may induce them.

* Corresponding author. Mailing address: University of Toronto, Clinical Sciences Division, Rm. 6271, Medical Sciences Building, Toronto, ON, Canada M5S 1A8. Phone: (416) 946-5805. Fax: (416) 978-8765. E-mail: mario.ostrowski{at}gmail.com

{triangledown} Published ahead of print on 23 April 2008.

Journal of Virology, July 2008, p. 6767-6771, Vol. 82, No. 13
0022-538X/08/$08.00+0     doi:10.1128/JVI.02550-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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