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Journal of Virology, June 2008, p. 5657-5663, Vol. 82, No. 11
0022-538X/08/$08.00+0     doi:10.1128/JVI.02556-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

New Complex Recombinant Genotype of Hepatitis B Virus Identified in Vietnam{triangledown}

Tran Thien Tuan Huy,1 Trinh Thi Ngoc,2 and Kenji Abe1*

Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan,1 National Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam2

Received 30 November 2007/ Accepted 10 March 2008

A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel intergenotypic recombination between genotypes A, C, and G. VH24 showed high similarity (98.3 to 98.9%) to the "aberrant strains" among Vietnamese isolates reported by Hannoun et al. (C. Hannoun et al., J. Gen. Virol. 81:2267-2272, 2000) and also had similar breakpoints of recombination. Phylogenetic analysis of the complete genome of these strains formed a separate clade. Furthermore, their pre-S/S gene-encoded seven unique conserved amino acid residues were not present in other genotypes. These findings support the designation of the new genotype I.

* Corresponding author. Mailing address: Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: (81) 3-5285-1111, ext. 2624. Fax: (81) 3-5285-1189. E-mail: kenjiabe{at}nih.go.jp

{triangledown} Published ahead of print on 19 March 2008.

Journal of Virology, June 2008, p. 5657-5663, Vol. 82, No. 11
0022-538X/08/$08.00+0     doi:10.1128/JVI.02556-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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