This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Legrand-Abravanel, F.
Right arrow Articles by Izopet, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Legrand-Abravanel, F.
Right arrow Articles by Izopet, J.

 Previous Article  |  Next Article 

Journal of Virology, April 2007, p. 4357-4362, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.02639-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

New Natural Intergenotypic (2/5) Recombinant of Hepatitis C Virus{triangledown}

Florence Legrand-Abravanel, Julie Claudinon, Florence Nicot, Martine Dubois, Sabine Chapuy-Regaud, Karine Sandres-Saune, Christophe Pasquier, and Jacques Izopet*

Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563-IFR30, 330 Avenue de Grande-Bretagne, TSA 40031, 31059 Toulouse Cédex 9, France

Received 29 November 2006/ Accepted 19 January 2007

A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.

* Corresponding author. Mailing address: Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563, IFR30, 330 Ave. de Grande-Bretagne, TSA 40031, 31059 Toulouse Cédex 9, France. Phone: (33) 5 67 69 04 24. Fax: (33) 5 67 69 04 25. E-mail: izopet.j{at}chu-toulouse.fr

{triangledown} Published ahead of print on 31 January 2007.

Journal of Virology, April 2007, p. 4357-4362, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.02639-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pacini, L., Graziani, R., Bartholomew, L., De Francesco, R., Paonessa, G. (2009). Naturally Occurring Hepatitis C Virus Subgenomic Deletion Mutants Replicate Efficiently in Huh-7 Cells and Are trans-Packaged In Vitro To Generate Infectious Defective Particles. J. Virol. 83: 9079-9093 [Abstract] [Full Text]  
  • Li, C., Lu, L., Wu, X., Wang, C., Bennett, P., Lu, T., Murphy, D. (2009). Complete genomic sequences for hepatitis C virus subtypes 4b, 4c, 4d, 4g, 4k, 4l, 4m, 4n, 4o, 4p, 4q, 4r and 4t. J. Gen. Virol. 90: 1820-1826 [Abstract] [Full Text]  
  • Xu, Z., Fan, X., Xu, Y., Di Bisceglie, A. M. (2008). Comparative Analysis of Nearly Full-Length Hepatitis C Virus Quasispecies from Patients Experiencing Viral Breakthrough during Antiviral Therapy: Clustered Mutations in Three Functional Genes, E2, NS2, and NS5a. J. Virol. 82: 9417-9424 [Abstract] [Full Text]  
  • Aaskov, J., Buzacott, K., Field, E., Lowry, K., Berlioz-Arthaud, A., Holmes, E. C. (2007). Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient. J. Gen. Virol. 88: 3334-3340 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»