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Journal of Virology, December 2007, p. 13932-13937, Vol. 81, No. 24
0022-538X/07/$08.00+0     doi:10.1128/JVI.01760-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antiretroviral Activity and Vif Sensitivity of Rhesus Macaque APOBEC3 Proteins{triangledown}

Cesar A. Virgen and Theodora Hatziioannou*

Aaron Diamond AIDS Research Center and the Rockefeller University, New York, New York

Received 11 August 2007/ Accepted 2 October 2007

The inability of human immunodeficiency virus type 1(HIV-1) to replicate in rhesus macaque cells is in part due to the failure of HIV-1 Vif to counteract the restriction factor APOBEC3G. However, in this study we demonstrate that several rhesus macaque APOBEC3 (rhAPOBEC3) proteins are capable of inhibiting HIV-1 infectivity. There was considerable variation in the ability of a panel of Vif proteins to induce degradation of rhAPOBEC3 proteins, and mutations within HIV-1 Vif that render it capable of degrading rhAPOBEC3G did not confer activity against other antiviral rhAPOBEC3 proteins. These findings suggest that multiple APOBEC3 proteins can contribute to primate lentivirus species tropism.

* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016. Phone: (212) 448-5091. Fax: (212) 448-5158. E-mail: thatziio{at}adarc.org

{triangledown} Published ahead of print on 17 October 2007.

Journal of Virology, December 2007, p. 13932-13937, Vol. 81, No. 24
0022-538X/07/$08.00+0     doi:10.1128/JVI.01760-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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