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Journal of Virology, December 2007, p. 12927-12935, Vol. 81, No. 23
0022-538X/07/$08.00+0     doi:10.1128/JVI.00931-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Interaction of Decay-Accelerating Factor with Coxsackievirus B3{triangledown}

Susan Hafenstein,1 Valorie D. Bowman,1 Paul R. Chipman,1 Carol M. Bator Kelly,1 Feng Lin,2 M. Edward Medof,2 and Michael G. Rossmann1*

Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, Indiana 47907-2054,1 Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 441062

Received 1 May 2007/ Accepted 24 August 2007

Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.

* Corresponding author. Mailing address: Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907-2054. Phone: (765) 494-4911. Fax: (765) 496-1189. E-mail: mr{at}purdue.edu

{triangledown} Published ahead of print on 5 September 2007.

Journal of Virology, December 2007, p. 12927-12935, Vol. 81, No. 23
0022-538X/07/$08.00+0     doi:10.1128/JVI.00931-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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Copyright © 2007 by the American Society for Microbiology. All rights reserved.