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 Previous Article

Journal of Virology, October 2007, p. 11549-11552, Vol. 81, No. 20
0022-538X/07/$08.00+0     doi:10.1128/JVI.00960-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus Type 1 Derivative with 7% Simian Immunodeficiency Virus Genetic Content Is Able To Establish Infections in Pig-Tailed Macaques{triangledown}

Tatsuhiko Igarashi,1 Ranjini Iyengar,1 Russel A. Byrum,2 Alicia Buckler-White,1 Robin L. Dewar,3 Charles E. Buckler,1 H. Clifford Lane,4 Kazuya Kamada,5 Akio Adachi,5 and Malcolm A. Martin1*

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,1 Bioqual, Rockville, Maryland 20850,2 Science Applications International Corporation—Frederick, Inc., Frederick, Maryland 21702,3 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,4 Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima 770-8503, Japan5

Received 3 May 2007/ Accepted 23 July 2007

A human immunodeficiency virus type 1 (HIV-1) derivative (HIVNL-DT5R) containing sequences encoding a 7-amino-acid segment of CA and the entire vif gene from simian immunodeficiency virus (SIV) was previously shown to establish spreading infections in cultured macaque peripheral blood mononuclear cells. To assess its replicative and disease-inducing properties in vivo, HIVNL-DT5R was inoculated into pig-tailed macaques. HIVNL-DT5R generated plasma viremia in all five of the monkeys and elicited humoral responses against all of the HIV-1 structural proteins but did not cause CD4+ T-lymphocyte depletion or clinical disease. Additional adaptation will be required to optimize infectivity in vivo.

* Corresponding author. Mailing address: Laboratory of Molecular Microbiology, NIAID, NIH, Bldg. 4, Room 315, 4 Center Drive, MSC 0460, Bethesda, MD 20892-0460. Phone: (301) 496-4012. Fax: (301) 402-0226. E-mail: malm{at}nih.gov

{triangledown} Published ahead of print on 1 August 2007.

Journal of Virology, October 2007, p. 11549-11552, Vol. 81, No. 20
0022-538X/07/$08.00+0     doi:10.1128/JVI.00960-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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