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Journal of Virology, January 2007, p. 1033-1036, Vol. 81, No. 2
0022-538X/07/$08.00+0     doi:10.1128/JVI.02271-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Expression of Viral MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma{triangledown}

Do Nyun Kim,1,{dagger} Hiun-Suk Chae,2,{dagger} Sang Taek Oh,1 Jin-Hyoung Kang,3 Cho Hyun Park,4 Won Sang Park,5 Kenzo Takada,6 Jae Myun Lee,7 Won-Keun Lee,8 and Suk Kyeong Lee1*

Research Institute of Immunobiology,1 Internal Medicine,2 Division of Medical Oncology,3 Departments of Surgery,4 Departments of Pathology, Catholic University of Korea, Seoul, Korea,5 Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan,6 Department of Microbiology, Yonsei University, Seoul, Korea,7 Division of Bioscience and Bioinformatics, Myongji University, Yongin, Kyunggi-do, Korea8

Received 17 October 2006/ Accepted 25 October 2006

Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.

* Corresponding author. Mailing address: Research Institute of Immunobiology, Department of Biomedical Sciences, Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea. Phone: 82-2-590-2396. Fax: 82-2-532-0575. E-mail: sukklee{at}catholic.ac.kr.

{triangledown} Published ahead of print on 1 November 2006.

{dagger} D.N.K. and H.-S. C. contributed equally to this work.

Journal of Virology, January 2007, p. 1033-1036, Vol. 81, No. 2
0022-538X/07/$08.00+0     doi:10.1128/JVI.02271-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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