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Journal of Virology, August 2007, p. 8833-8837, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00612-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Borna Disease Virus Infection Impairs Synaptic Plasticity{triangledown}

Romain Volmer,1,2,{dagger} Christine M. A. Prat,1,2 Gwendal Le Masson,3 André Garenne,3,{ddagger} and Daniel Gonzalez-Dunia1,2*,{ddagger}

INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France,1 Université Paul-Sabatier, Toulouse, France,2 INSERM, U862, and Université Bordeaux 2, Bordeaux, France3

Received 22 March 2007/ Accepted 24 May 2007

The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood. To analyze the electrophysiological properties of neurons infected with BDV, we used cultures of neurons grown on multielectrode arrays, allowing a real-time monitoring of the electrical activity across the network shaped by synaptic transmission. Although infection did not affect spontaneous neuronal activity, it selectively blocked activity-dependent enhancement of neuronal network activity, one form of synaptic plasticity thought to be important for learning and memory. These findings highlight the original mechanism of the neuronal dysfunction caused by noncytolytic infection with BDV.

* Corresponding author. Mailing address: Inserm U563, CPTP bat B, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France. Phone: 33 5 6274 4511. Fax: 33 5 6274 4558. E-mail: Daniel.Dunia{at}toulouse.inserm.fr

{triangledown} Published ahead of print on 6 June 2007.

{dagger} Present address: UMR1225, INRA, École Nationale Vétérinaire de Toulouse, France.

{ddagger} A.G. and D.G.-D. codirected this work.

Journal of Virology, August 2007, p. 8833-8837, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00612-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Suberbielle, E., Stella, A., Pont, F., Monnet, C., Mouton, E., Lamouroux, L., Monsarrat, B., Gonzalez-Dunia, D. (2008). Proteomic Analysis Reveals Selective Impediment of Neuronal Remodeling upon Borna Disease Virus Infection. J. Virol. 82: 12265-12279 [Abstract] [Full Text]  


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