This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ho, S.-h.
Right arrow Articles by Cheng-Mayer, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ho, S.-h.
Right arrow Articles by Cheng-Mayer, C.

 Previous Article  |  Next Article 

Journal of Virology, August 2007, p. 8621-8633, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00759-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Coreceptor Switch in R5-Tropic Simian/Human Immunodeficiency Virus-Infected Macaques{triangledown}

Siu-hong Ho,1 Silvana Tasca,1 Lili Shek,1 Amy Li,1 Agegnehu Gettie,1 James Blanchard,2 Daniel Boden,1 and Cecilia Cheng-Mayer1*

Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave., 7th Floor, New York, New York 10016,1 Tulane National Primate Research Center, Tulane University Medical Center, 18702 Three Rivers Road, Covington, Louisiana 704332

Received 9 April 2007/ Accepted 17 May 2007

The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in ~50% of human immunodeficiency virus type 1 (HIV-1) subtype B-infected individuals as disease advances is not well understood. Among the reasons proposed are target cell limitation and better immune recognition of the CXCR4 (X4)-tropic compared to the CCR5 (R5)-tropic virus. We document here X4 virus emergence in a rhesus macaque (RM) infected with R5-tropic simian/human immunodeficiency virus, demonstrating that coreceptor switch can happen in a nonhuman primate model of HIV/AIDS. The switch to CXCR4 usage in RM requires envelope sequence changes in the V3 loop that are similar to those found in humans, suggesting that the R5-to-X4 evolution pathways in the two hosts overlap. Interestingly, compared to the inoculating R5 virus, the emerging CXCR4-using virus is highly neutralization sensitive. This finding, coupled with the observation of X4 evolution and appearance in an animal with undetectable circulating virus-specific antibody and low cellular immune responses, lends further support to an inhibitory role of antiviral immunity in HIV-1 coreceptor switch.

* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave., 7th Floor, New York, NY 10016. Phone: (212) 448-5080. Fax: (212) 448-5158. E-mail: cmayer{at}adarc.org

{triangledown} Published ahead of print on 30 May 2007.

Journal of Virology, August 2007, p. 8621-8633, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00759-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Del Prete, G. Q., Haggarty, B., Leslie, G. J., Jordan, A. P. O., Romano, J., Wang, N., Wang, J., Holmes, M. C., Montefiori, D. C., Hoxie, J. A. (2009). Derivation and Characterization of a Simian Immunodeficiency Virus SIVmac239 Variant with Tropism for CXCR4. J. Virol. 83: 9911-9922 [Abstract] [Full Text]  
  • Coetzer, M., Nedellec, R., Salkowitz, J., McLaughlin, S., Liu, Y., Heath, L., Mullins, J. I., Mosier, D. E. (2008). Evolution of CCR5 Use before and during Coreceptor Switching. J. Virol. 82: 11758-11766 [Abstract] [Full Text]  
  • Tasca, S., Ho, S.-H., Cheng-Mayer, C. (2008). R5X4 Viruses Are Evolutionary, Functional, and Antigenic Intermediates in the Pathway of a Simian-Human Immunodeficiency Virus Coreceptor Switch. J. Virol. 82: 7089-7099 [Abstract] [Full Text]  
  • Ho, S.-h., Trunova, N., Gettie, A., Blanchard, J., Cheng-Mayer, C. (2008). Different Mutational Pathways to CXCR4 Coreceptor Switch of CCR5-Using Simian-Human Immunodeficiency Virus. J. Virol. 82: 5653-5656 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»