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Journal of Virology, July 2007, p. 7269-7273, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.00356-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Predictable {alpha}ß T-Cell Receptor Selection toward an HLA-B*3501-Restricted Human Cytomegalovirus Epitope{triangledown}

Rebekah M. Brennan,1,{dagger} John J. Miles,1,2,{dagger} Sharon L. Silins,1 Melissa J. Bell,1 Jacqueline M. Burrows,1 and Scott R. Burrows1*

Cellular Immunology Laboratory and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Australia,1 School of Population Health, University of Queensland, Brisbane, Australia2

Received 19 February 2007/ Accepted 17 April 2007

Human cytomegalovirus (HCMV) elicits a very large burden on the immune system, with approximately one in ten T cells being reserved solely to manage this infection. However, information on the clonotypic composition of these vast T-cell populations is limited. In this study, we sequenced 116 T-cell receptor (TcR) {alpha}/ß-chains specific for the highly immunogenic HLA-B*3501-resticted epitope IPSINVHHY from the pp65 antigen. Interestingly, T cells recovered from all donors bore an identical or near-identical TRBV28/TRBJ1-4/TRAV17/TRAJ33 TcR. The ability to predict the responding {alpha}ß TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology.

* Corresponding author. Mailing address: Queensland Institute of Medical Research, 300 Herston Road, Brisbane 4029, Australia. Phone: 61-7-3845-3793. Fax: 61-7-3845-3510. E-mail: scott.burrows{at}qimr.edu.au

{triangledown} Published ahead of print on 25 April 2007.

{dagger} R.M.B. and J.J.M. contributed equally to this work.

Journal of Virology, July 2007, p. 7269-7273, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.00356-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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