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 Previous Article

Journal of Virology, January 2007, p. 434-438, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01754-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection{triangledown}

Cheryl L. Day,1,2,3 Photini Kiepiela,2 Alasdair J. Leslie,1 Mary van der Stok,2 Kriebashne Nair,2 Nasreen Ismail,2 Isobella Honeyborne,1 Hayley Crawford,1 Hoosen M. Coovadia,2 Philip J. R. Goulder,1,2,3 Bruce D. Walker,2,3,4 and Paul Klenerman1*

Nuffield Department of Medicine, The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom,1 HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa,2 Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115,3 Howard Hughes Medical Institute, Chevy Chase, Maryland 201854

Received 14 August 2006/ Accepted 9 October 2006

The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranulation, only proliferation showed a significant correlation with viral load. This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation.

* Corresponding author. Mailing address: Nuffield Department of Medicine, The Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom. Phone: 44 1865 281885. Fax: 44 1865 281890. E-mail: paul.klenerman{at}medawar.ox.ac.uk.

{triangledown} Published ahead of print on 18 October 2006.

Journal of Virology, January 2007, p. 434-438, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01754-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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