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Journal of Virology, April 2006, p. 3675-3678, Vol. 80, No. 7
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.7.3675-3678.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparison of the Mutation Rates of Human Influenza A and B Viruses

Eri Nobusawa1* and Katsuhiko Sato2

Department of Microbiology and Infection, Nagoya City University Graduate School of Medical Science,1 Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya City, Japan2

Received 28 September 2005/ Accepted 13 January 2006

Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 x 10–6 and 0.6 x 10–6 mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates.

* Corresponding author. Mailing address: Department of Microbiology and Infection, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya City 467-8601, Japan. Phone: 81-52-853-8190. Fax: 81-52-853-3638. E-mail:nobusawa{at}med.nagoya-cu.ac.jp.

Journal of Virology, April 2006, p. 3675-3678, Vol. 80, No. 7
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.7.3675-3678.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hai, R., Martinez-Sobrido, L., Fraser, K. A., Ayllon, J., Garcia-Sastre, A., Palese, P. (2008). Influenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine Approach. J. Virol. 82: 10580-10590 [Abstract] [Full Text]  


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