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Journal of Virology, April 2006, p. 3660-3665, Vol. 80, No. 7
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.7.3660-3665.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Brd4 Is Involved in Multiple Processes of the Bovine Papillomavirus Type 1 Life Cycle

Ivar Ilves,1 Kristina Mäemets,2 Toomas Silla,2 Kadri Janikson,2 and Mart Ustav1,2*

Institute of Technology,1 Department of Microbiology and Virology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia2

Received 16 September 2005/ Accepted 18 January 2006

Brd4 protein has been proposed to act as a cellular receptor for the bovine papillomavirus type 1 (BPV1) E2 protein in the E2-mediated chromosome attachment and mitotic segregation of viral genomes. Here, we provide data that show the involvement of Brd4 in multiple early functions of the BPV1 life cycle, suggest a Brd4-dependent mechanism for E2-dependent transcription activation, and indicate the role of Brd4 in papillomavirus and polyomavirus replication as well as cell-specific utilization of Brd4-linked features in BPV1 DNA replication. Our data also show the potential therapeutic value of the disruption of the E2-Brd4 interaction for the development of antiviral drugs.

* Corresponding author. Mailing address: Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia. Phone: 372 7374 800. Fax: 372 7374 900. E-mail: ustav{at}ebc.ee.

Journal of Virology, April 2006, p. 3660-3665, Vol. 80, No. 7
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.7.3660-3665.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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