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Journal of Virology, March 2006, p. 3104-3107, Vol. 80, No. 6
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.6.3104-3107.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Characterization of a Koala Retrovirus

Nidia M. Oliveira, Karen B. Farrell, and Maribeth V. Eiden*

Section on Molecular Virology, National Institute of Mental Health, NIH, Bethesda, Maryland

Received 18 October 2005/ Accepted 27 December 2005

Recently, a new endogenous koala gammaretrovirus, designated KoRV, was isolated from koalas. The KoRV genome shares 78% nucleotide identity with another gammaretrovirus, gibbon ape leukemia virus (GALV). KoRV is endogenous in koalas, while GALV is exogenous, suggesting that KoRV predates GALV and that gibbons and koalas acquired the virus at different times from a common source. We have determined that subtle adaptive differences between the KoRV and GALV envelope genes account for differences in their receptor utilization properties. KoRV represents a unique example of a gammaretrovirus whose envelope has evolved to allow for its expanded host range and zoonotic potential.

* Corresponding author. Mailing address: Section on Molecular Virology, National Institute of Mental Health, NIH, 49 Convent Drive, MSC 4483, Bethesda, MD 20892-4483. Phone: (301) 402-1641. Fax: (301) 402-5358. E-mail: eidenm{at}mail.nih.gov.

Journal of Virology, March 2006, p. 3104-3107, Vol. 80, No. 6
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.6.3104-3107.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Oliveira, N. M., Satija, H., Kouwenhoven, I. A., Eiden, M. V. (2007). Changes in viral protein function that accompany retroviral endogenization. Proc. Natl. Acad. Sci. USA 104: 17506-17511 [Abstract] [Full Text]  
  • Fiebig, U., Hartmann, M. G., Bannert, N., Kurth, R., Denner, J. (2006). Transspecies transmission of the endogenous koala retrovirus.. J. Virol. 80: 5651-5654 [Abstract] [Full Text]  


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