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Journal of Virology, March 2006, p. 2578-2581, Vol. 80, No. 5
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.5.2578-2581.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Level of Reverse Transcriptase (RT) in Human Immunodeficiency Virus Type 1 Particles Affects Susceptibility to Nonnucleoside RT Inhibitors but Not to Lamivudine

Zandrea Ambrose,1 John G. Julias,1,2 Paul L. Boyer,1 Vineet N. KewalRamani,1 and Stephen H. Hughes1*

HIV Drug Resistance Program,1 Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, MD 217022

Received 6 July 2005/ Accepted 7 December 2005

We investigated the relationship between the level of reverse transcriptase (RT) in human immunodeficiency virus type 1 (HIV-1) particles and susceptibility to nonnucleoside reverse transcriptase inhibitors (NNRTIs). HIV-1 virions containing different active levels of RT were generated. Susceptibility to the NNRTIs efavirenz and nevirapine was inversely proportional to the level of enzymatically active RT. However, the sensitivity of HIV-1 to the nucleoside analog 3TC was not affected by the level of RT per particle. These data indicate that the susceptibility of HIV-1 to NNRTIs is influenced by RT activity.

* Corresponding author. Mailing address: NCI-Frederick, Building 539, Room 130A, Frederick, MD 21702. Phone: (301) 846-1619. Fax: (301) 846-6966. E-mail: hughes{at}ncifcrf.gov.

Journal of Virology, March 2006, p. 2578-2581, Vol. 80, No. 5
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.5.2578-2581.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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