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Journal of Virology, February 2006, p. 1152-1159, Vol. 80, No. 3
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.3.1152-1159.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Transduction of Nondividing Human Macrophages with Gammaretrovirus-Derived Vectors

Loraine Jarrosson-Wuilleme,1 Caroline Goujon,1 Jeanine Bernaud,2 Dominique Rigal,2 Jean-Luc Darlix,1 and Andrea Cimarelli1*

LaboRetro, INSERM U412, Ecole Normale Supérieure de Lyon, IFR 128 BioSciences Lyon-Gerland,1 Etablissement Transfusion Sanguine, Lyon, France2

Received 4 July 2005/ Accepted 4 November 2005

It is commonly accepted that infection of nondividing cells by gammaretroviruses such as the murine leukemia viruses is inefficient due to their inability to cross the nuclear envelope barrier. Challenging this notion, we now show that human nondividing macrophages display a specific window of susceptibility to transduction with a Friend murine leukemia virus (F-MLV)-derived vector during their differentiation from monocytes. This finding suggests that factors other than the nuclear membrane govern permissiveness to gammaretroviral infection and raises the possibility of using the macrophage tropism of F-MLV in gene therapy.

* Corresponding author. Mailing address: LaboRetro, INSERM U412, Ecole Normale Supérieure de Lyon, IFR 128 BioSciences Lyon-Gerland, 46 Allée d'Italie, 69364 Lyon, France. Phone: (33) 4 72728051. Fax: (33) 4 72728777. E-mail: acimarel{at}ens-lyon.fr.

Journal of Virology, February 2006, p. 1152-1159, Vol. 80, No. 3
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.3.1152-1159.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Arfi, V., Lienard, J., Nguyen, X.-N., Berger, G., Rigal, D., Darlix, J.-L., Cimarelli, A. (2009). Characterization of the Behavior of Functional Viral Genomes during the Early Steps of Human Immunodeficiency Virus Type 1 Infection. J. Virol. 83: 7524-7535 [Abstract] [Full Text]  
  • Arfi, V., Riviere, L., Jarrosson-Wuilleme, L., Goujon, C., Rigal, D., Darlix, J.-L., Cimarelli, A. (2008). Characterization of the Early Steps of Infection of Primary Blood Monocytes by Human Immunodeficiency Virus Type 1. J. Virol. 82: 6557-6565 [Abstract] [Full Text]  
  • Yu, J. H., Schaffer, D. V. (2006). High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells.. J. Virol. 80: 8981-8988 [Abstract] [Full Text]  


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