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Journal of Virology, December 2006, p. 12402-12407, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.01709-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Proviral Progeny of Heterodimeric Virions Reveal a High Crossover Rate for Human Immunodeficiency Virus Type 2{triangledown}

Sayandip Mukherjee,1,2 Hui-Ling Rose Lee,1,2 Yacov Ron,1 and Joseph P. Dougherty1*

Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854,1 Graduate Program in Molecular Biosciences, Rutgers University, New Brunswick, New Jersey 089012

Received 7 August 2006/ Accepted 26 September 2006

Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS in humans, exhibits a very high rate of recombination. Bearing in mind the significant epidemiological and clinical contrast between HIV-2 and HIV-1 as well as the critical role that recombination plays in viral evolution, we examined the nature of HIV-2 recombination. Towards this end, a strategy was devised to measure the rate of crossover of HIV-2 by evaluating recombinant progeny produced exclusively by heterodimeric virions. The results showed that HIV-2 exhibits a crossover rate similar to that of HIV-1 and murine leukemia virus, indicating that the extremely high rate of crossover is a common retroviral feature.

* Corresponding author. Mailing address: Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854. Phone: (732) 235-4588. Fax: (732) 235-5223. E-mail: doughejp{at}umdnj.edu.

{triangledown} Published ahead of print on 4 October 2006.

Journal of Virology, December 2006, p. 12402-12407, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.01709-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Onafuwa-Nuga, A., Telesnitsky, A. (2009). The Remarkable Frequency of Human Immunodeficiency Virus Type 1 Genetic Recombination. Microbiol. Mol. Biol. Rev. 73: 451-480 [Abstract] [Full Text]  
  • Motomura, K., Chen, J., Hu, W.-S. (2008). Genetic Recombination between Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2, Two Distinct Human Lentiviruses. J. Virol. 82: 1923-1933 [Abstract] [Full Text]  


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