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Journal of Virology, November 2006, p. 10858-10861, Vol. 80, No. 21
0022-538X/06/$08.00+0     doi:10.1128/JVI.01298-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

JC Virus Minor Capsid Proteins Vp2 and Vp3 Are Essential for Virus Propagation

M. L. Gasparovic,2 G. V. Gee,3 and W. J. Atwood1,2*

Department of Molecular Biology, Cell Biology and Biochemistry,1 Graduate Program in Molecular Biology, Cell Biology and Biochemistry,2 Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 029123

Received 20 June 2006/ Accepted 7 August 2006

Virus-encoded capsid proteins play a major role in the life cycles of all viruses. The JC virus capsid is composed of 72 pentamers of the major capsid protein Vp1, with one of the minor coat proteins Vp2 or Vp3 in the center of each pentamer. Vp3 is identical to two-thirds of Vp2, and these proteins share a DNA binding domain, a nuclear localization signal, and a Vp1-interacting domain. We demonstrate here that both the minor proteins and the myristylation site on Vp2 are essential for the viral life cycle, including the proper packaging of its genome.

* Corresponding author. Mailing address: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Box G-E434, Providence, RI 02903. Phone: (401) 863-3116. Fax: (401) 863-9653. E-mail: Walter_Atwood{at}Brown.edu.

Journal of Virology, November 2006, p. 10858-10861, Vol. 80, No. 21
0022-538X/06/$08.00+0     doi:10.1128/JVI.01298-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nakanishi, A., Itoh, N., Li, P. P., Handa, H., Liddington, R. C., Kasamatsu, H. (2007). Minor Capsid Proteins of Simian Virus 40 Are Dispensable for Nucleocapsid Assembly and Cell Entry but Are Required for Nuclear Entry of the Viral Genome. J. Virol. 81: 3778-3785 [Abstract] [Full Text]  


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