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Journal of Virology, October 2006, p. 9916-9920, Vol. 80, No. 19
0022-538X/06/$08.00+0     doi:10.1128/JVI.02693-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Induction of Cell-Cell Fusion from Without by Human Herpesvirus 6B

Simon Metz Pedersen, Bodil Øster, Bettina Bundgaard, and Per Höllsberg*

Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, Aarhus DK-8000, Denmark

Received 22 December 2005/ Accepted 20 February 2006

Human herpesvirus (HHV) 6A induce fusion from without (FFWO), whereas HHV-6B is believed to be ineffective in this process. Here, we demonstrate that HHV-6B induces rapid fusion in both epithelial cells and lymphocytes. The fusion was identified 1 h postinfection, could be inhibited by antibodies to HHV-6B gH and to the cellular receptor CD46, and was dependent on virus titer but independent of de novo protein synthesis and UV inactivation of the virus. Comparisons indicate that HHV-6A is only 10-fold more effective in inducing FFWO than HHV-6B. These data demonstrate that HHV-6B can induce FFWO in epithelial cells and lymphocytes.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark. Phone: 45 8942 1772. Fax: 45 8619 6128. E-mail: ph{at}microbiology.au.dk.

Journal of Virology, October 2006, p. 9916-9920, Vol. 80, No. 19
0022-538X/06/$08.00+0     doi:10.1128/JVI.02693-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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