This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fuse, S.
Right arrow Articles by Usherwood, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fuse, S.
Right arrow Articles by Usherwood, E. J.

 Previous Article  |  Next Article 

Journal of Virology, September 2006, p. 9159-9170, Vol. 80, No. 18
0022-538X/06/$08.00+0     doi:10.1128/JVI.00422-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68

Shinichiro Fuse,1 Joshua J. Obar,1 Sarah Bellfy,1 Erica K. Leung,2 Weijun Zhang,1 and Edward J. Usherwood1*

Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756,1 Honours Biology & Pharmacology Program, McMaster University, Hamilton, Ontario, Canada L8S 4L82

Received 1 March 2006/ Accepted 27 June 2006

The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells serve as an important costimulatory signal in the activation of T cells. Although the simplistic two-signal hypothesis has been challenged in recent years by the identification of different costimulators, this classical pathway has been shown to significantly impact antiviral humoral and cellular immune responses. How the CD80/CD86-CD28 pathway affects the control of chronic or latent infections has been less well characterized. In this study, we investigated its role in antiviral immune responses against murine gammaherpesvirus 68 (MHV-68) and immune surveillance using CD80/CD86–/– mice. In the absence of CD80/CD86, primary antiviral CD8+ T-cell responses and the induction of neutralizing antibodies were severely impaired. During long-term immune surveillance, the virus-specific CD8+ T cells were impaired in IFN-{gamma} production and secondary expansion and exhibited an altered phenotype. Surprisingly, a low level of viral reactivation in the lung was observed, and this effect was independent of CD28 and CTLA-4. Thus, CD80 and CD86, signaling through CD28 and possibly another unidentified receptor, are required for optimal immune surveillance and antiviral immune responses to murine gammaherpesvirus.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 1 Medical Center Dr., Lebanon, NH 03756. Phone: (603) 650-7730. Fax: (603) 650-6223. E-mail: edward.j.usherwood{at}dartmouth.edu.

Journal of Virology, September 2006, p. 9159-9170, Vol. 80, No. 18
0022-538X/06/$08.00+0     doi:10.1128/JVI.00422-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Krug, L. T., Collins, C. M., Gargano, L. M., Speck, S. H. (2009). NF-{kappa}B p50 Plays Distinct Roles in the Establishment and Control of Murine Gammaherpesvirus 68 Latency. J. Virol. 83: 4732-4748 [Abstract] [Full Text]  
  • Salek-Ardakani, S., Arens, R., Flynn, R., Sette, A., Schoenberger, S. P., Croft, M. (2009). Preferential Use of B7.2 and Not B7.1 in Priming of Vaccinia Virus-Specific CD8 T Cells. J. Immunol. 182: 2909-2918 [Abstract] [Full Text]  
  • Fuse, S., Zhang, W., Usherwood, E. J. (2008). Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response. J. Immunol. 180: 1148-1157 [Abstract] [Full Text]  
  • Fuse, S., Bellfy, S., Yagita, H., Usherwood, E. J. (2007). CD8+ T Cell Dysfunction and Increase in Murine Gammaherpesvirus Latent Viral Burden in the Absence of 4-1BB Ligand. J. Immunol. 178: 5227-5236 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»