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Journal of Virology, July 2006, p. 6712-6715, Vol. 80, No. 13
0022-538X/06/$08.00+0     doi:10.1128/JVI.00453-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Challenging the Role of Microtubules in Tobacco Mosaic Virus Movement by Drug Treatments Is Disputable

Mark Seemanpillai, Rabab Elamawi, Christophe Ritzenthaler, and Manfred Heinlein*

Institut Biologie Moléculaire des Plantes, 12 Rue du Général Zimmer, 67084 Strasbourg Cedex, France

Received 3 March 2006/ Accepted 10 April 2006

The movement protein (MP) of Tobacco mosaic virus interacts with microtubules during infection. Although this interaction is correlated with the function of MP in the cell-to-cell transport of viral RNA, a direct role of microtubules in the movement process was recently challenged by studies involving the treatment of plants with inhibitors of microtubule polymerization. Here, we report evidence suggesting that such treatments may not efficiently disrupt all microtubules. Thus, results obtained from studies using microtubule inhibitors may have to remain open to interpretation with regard to the involvement of microtubules in viral RNA trafficking.

* Corresponding author. Mailing address: Institut Biologie Moléculaire des Plantes, 12 Rue du Général Zimmer, 67084 Strasbourg Cedex, France. Phone: 33 3 88 41 72 58. Fax: 33 3 88 61 44 42. E-mail: manfred.heinlein{at}ibmp-ulp.u-strasbg.fr.

Journal of Virology, July 2006, p. 6712-6715, Vol. 80, No. 13
0022-538X/06/$08.00+0     doi:10.1128/JVI.00453-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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