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Journal of Virology, July 2006, p. 6259-6266, Vol. 80, No. 13
0022-538X/06/$08.00+0     doi:10.1128/JVI.00084-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immunogenicity of Cytopathic and Noncytopathic Viral Vectors

Gabriela Plesa,1 Philip M. McKenna,2 Matthias J. Schnell,2 and Laurence C. Eisenlohr1*

Department of Microbiology and Immunology,1 Department of Biochemistry and Molecular Pharmacology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 191072

Received 12 January 2006/ Accepted 7 April 2006

The impact of cytolytic versus noncytolytic viral infections on host responses is not well understood, due to limitations of the systems that have been used to address this issue. Using paired cytopathic and noncytopathic rabies viruses that differ by only two amino acids, we investigated several fundamental aspects of the immune response to these viral vectors. Greater cytopathic capacity translated into a greater degree of cross-priming to CD8+ T cells (TCD8+) and more-robust short-term humoral and cellular responses. However, long-term responses to the two viruses were similar, suggesting that direct priming drives the bulk of the TCD8+ antirabies response and that enhanced acute responses associated with greater virally mediated cellular destruction were balanced by other factors, such as prolonged antigen expression associated with noncytopathic virus. Such compensatory mechanisms may be in place to ensure comparable immunologic memories to various pathogens.

* Corresponding author. Mailing address: Thomas Jefferson University, Kimmel Cancer Center, 233 S. 10th Street, BLSB 730, Philadelphia, PA 19107. Phone: (215) 503-4540. Fax: (215) 923-4153. E-mail: Laurence.Eisenlohr{at}mail.jci.tju.edu.

Journal of Virology, July 2006, p. 6259-6266, Vol. 80, No. 13
0022-538X/06/$08.00+0     doi:10.1128/JVI.00084-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Snook, A. E., Stafford, B. J., Li, P., Tan, G., Huang, L., Birbe, R., Schulz, S., Schnell, M. J., Thakur, M., Rothstein, J. L., Eisenlohr, L. C., Waldman, S. A. (2008). Guanylyl Cyclase C-Induced Immunotherapeutic Responses Opposing Tumor Metastases Without Autoimmunity. JNCI J Natl Cancer Inst 100: 950-961 [Abstract] [Full Text]  
  • Plesa, G., Snook, A. E., Waldman, S. A., Eisenlohr, L. C. (2008). Derivation and Fluidity of Acutely Induced Dysfunctional CD8+ T Cells. J. Immunol. 180: 5300-5308 [Abstract] [Full Text]  


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