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Journal of Virology, June 2006, p. 5651-5654, Vol. 80, No. 11
0022-538X/06/$08.00+0     doi:10.1128/JVI.02597-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Transspecies Transmission of the Endogenous Koala Retrovirus

Uwe Fiebig,1 Manuel Garcia Hartmann,2 Norbert Bannert,1 Reinhard Kurth,1 and Joachim Denner1*

Robert Koch Institute, 13353 Berlin,1 Zoo Duisburg, 47058 Duisburg, Germany2

Received 16 December 2005/ Accepted 8 March 2006

The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods for virus detection. The KoRV transmembrane envelope protein (p15E) was cloned and expressed, and p15E-specific neutralizing antibodies able to prevent virus infection in vitro were developed. Finally, evidence for immunosuppressive properties of the KoRV was obtained.

* Corresponding author. Mailing address: Robert Koch Institute, Nordufer 20, D-13353 Berlin, Germany. Phone: 49 30 4547 2800. Fax: 49 30 4547 2801. E-mail: DennerJ{at}rki.de.

Journal of Virology, June 2006, p. 5651-5654, Vol. 80, No. 11
0022-538X/06/$08.00+0     doi:10.1128/JVI.02597-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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