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Journal of Virology, January 2006, p. 537-540, Vol. 80, No. 1
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.1.537-540.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Respiratory Syncytial Virus (RSV) Infects Neuronal Cells and Processes That Innervate the Lung by a Process Involving RSV G Protein

Xia-qing Li,1 Zhen F. Fu,1,2 Rene Alvarez,2 Christine Henderson,2 and Ralph A. Tripp2*

Center for Disease Intervention, Department of Infectious Diseases,1 Department of Pathology, University of Georgia, College of Veterinary Medicine, Athens, Georgia2

Received 23 June 2005/ Accepted 3 October 2005

Respiratory syncytial virus (RSV) is a primary cause of morbidity and life-threatening lower respiratory tract disease in infants and young children. Children with acute RSV bronchiolitis often develop respiratory sequelae, but the disease mechanisms are poorly understood. Mounting evidence suggests that RSV may mediate persistent infection. Using immunohistochemistry to identify RSV and RSV-infected cell types, we show that RSV infects primary neurons and neuronal processes that innervate the lungs through a process that involves RSV G protein and the G protein CX3C motif. These findings suggest a mechanism for disease chronicity and have important implications for RSV disease intervention strategies.

* Corresponding author. Mailing address: Department of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, GA 30602. Phone: (706) 542-1557. Fax: (706) 583-0176. E-mail: rtripp{at}vet.uga.edu.

Journal of Virology, January 2006, p. 537-540, Vol. 80, No. 1
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.1.537-540.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Liu, Y., Haas, D. L., Poore, S., Isakovic, S., Gahan, M., Mahalingam, S., Fu, Z. F., Tripp, R. A. (2009). Human Metapneumovirus Establishes Persistent Infection in the Lungs of Mice and Is Reactivated by Glucocorticoid Treatment. J. Virol. 83: 6837-6848 [Abstract] [Full Text]  
  • Bitko, V., Musiyenko, A., Barik, S. (2007). Viral Infection of the Lungs through the Eye. J. Virol. 81: 783-790 [Abstract] [Full Text]  


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