This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Unsoeld, H.
Right arrow Articles by Pircher, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Unsoeld, H.
Right arrow Articles by Pircher, H.

 Previous Article  |  Next Article 

Journal of Virology, April 2005, p. 4510-4513, Vol. 79, No. 7
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.7.4510-4513.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Complex Memory T-Cell Phenotypes Revealed by Coexpression of CD62L and CCR7

Heike Unsoeld and Hanspeter Pircher*

Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany

Received 20 July 2004/ Accepted 22 November 2004

Antigen-experienced T cells have been divided into CD62L+ CCR7+ central memory (TCM) and CD62L– CCR7– effector memory (TEM) cells. Here, we examined coexpression of CD62L and CCR7 in lymphocytic choriomeningitis virus-specific memory CD8 T cells from both lymphoid and nonlymphoid tissues. Three main points emerged: firstly, memory cells frequently expressed a mixed CD62L– CCR7+ phenotype that differed from the phenotypes of classical TEM and TCM cells; secondly, TCM cells were not restricted to lymphoid organs but were also present in significant numbers in nonlymphoid tissues; and thirdly, a major shift from a TCM to TEM phenotype was found in memory cells that had been stimulated repetitively with antigen.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Hygiene, Department of Immunology, Hermann-Herder-Str. 11, University of Freiburg, D-79104 Freiburg, Germany. Phone: 49 761 203 6521. Fax: 49 761 203 6577. E-mail: hanspeter.pircher{at}uniklinik-freiburg.de.

Journal of Virology, April 2005, p. 4510-4513, Vol. 79, No. 7
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.7.4510-4513.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Munitic, I., Decaluwe, H., Evaristo, C., Lemos, S., Wlodarczyk, M., Worth, A., Le Bon, A., Selin, L. K., Riviere, Y., Di Santo, J. P., Borrow, P., Rocha, B. (2009). Epitope Specificity and Relative Clonal Abundance Do Not Affect CD8 Differentiation Patterns during Lymphocytic Choriomeningitis Virus Infection. J. Virol. 83: 11795-11807 [Abstract] [Full Text]  
  • Waugh, C., Sinclair, L., Finlay, D., Bayascas, J. R., Cantrell, D. (2009). Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation. Mol. Cell. Biol. 29: 5952-5962 [Abstract] [Full Text]  
  • Wirth, T. C., Badovinac, V. P., Zhao, L., Dailey, M. O., Harty, J. T. (2009). Differentiation of Central Memory CD8 T Cells Is Independent of CD62L-Mediated Trafficking to Lymph Nodes. J. Immunol. 182: 6195-6206 [Abstract] [Full Text]  
  • Shen, C.-H., Ge, Q., Talay, O., Eisen, H. N., Garcia-Sastre, A., Chen, J. (2008). Loss of IL-7R and IL-15R Expression Is Associated with Disappearance of Memory T Cells in Respiratory Tract following Influenza Infection. J. Immunol. 180: 171-178 [Abstract] [Full Text]  
  • Sarkar, S., Teichgraber, V., Kalia, V., Polley, A., Masopust, D., Harrington, L. E., Ahmed, R., Wherry, E. J. (2007). Strength of Stimulus and Clonal Competition Impact the Rate of Memory CD8 T Cell Differentiation. J. Immunol. 179: 6704-6714 [Abstract] [Full Text]  
  • Marzo, A. L., Yagita, H., Lefrancois, L. (2007). Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells. J. Immunol. 179: 36-40 [Abstract] [Full Text]  
  • Zhang, N., Sadun, R. E., Arias, R. S., Flanagan, M. L., Sachsman, S. M., Nien, Y.-C., Khawli, L. A., Hu, P., Epstein, A. L. (2007). Targeted and Untargeted CD137L Fusion Proteins for the Immunotherapy of Experimental Solid Tumors. Clin. Cancer Res. 13: 2758-2767 [Abstract] [Full Text]  
  • Kapina, M. A., Shepelkova, G. S., Mischenko, V. V., Sayles, P., Bogacheva, P., Winslow, G., Apt, A. S., Lyadova, I. V. (2007). CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-{gamma}, and Protect the Host against Tuberculosis Infection. J. Immunol. 178: 976-985 [Abstract] [Full Text]  
  • Klonowski, K. D., Marzo, A. L., Williams, K. J., Lee, S.-J., Pham, Q.-M., Lefrancois, L. (2006). CD8 T Cell Recall Responses Are Regulated by the Tissue Tropism of the Memory Cell and Pathogen. J. Immunol. 177: 6738-6746 [Abstract] [Full Text]  
  • Ha, S.-J., Park, S.-H., Kim, H.-J., Kim, S.-C., Kang, H.-J., Lee, E.-G., Kwon, S.-G., Kim, B.-M., Lee, S.-H., Kim, W.-B., Sung, Y.-C., Cho, S.-N. (2006). Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination.. Infect. Immun. 74: 4954-4959 [Abstract] [Full Text]  
  • Boettler, T., Panther, E., Bengsch, B., Nazarova, N., Spangenberg, H. C., Blum, H. E., Thimme, R. (2006). Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8+ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection.. J. Virol. 80: 3532-3540 [Abstract] [Full Text]  
  • Whitmire, J. K., Benning, N., Whitton, J. L. (2006). Precursor Frequency, Nonlinear Proliferation, and Functional Maturation of Virus-Specific CD4+ T Cells.. J. Immunol. 176: 3028-3036 [Abstract] [Full Text]  
  • Wei, C.-H., Trenney, R., Sanchez-Alavez, M., Marquardt, K., Woodland, D. L., Henriksen, S. J., Sherman, L. A. (2005). Tissue-Resident Memory CD8+ T Cells Can Be Deleted by Soluble, but Not Cross-Presented Antigen. J. Immunol. 175: 6615-6623 [Abstract] [Full Text]  
  • Thimme, R., Appay, V., Koschella, M., Panther, E., Roth, E., Hislop, A. D., Rickinson, A. B., Rowland-Jones, S. L., Blum, H. E., Pircher, H. (2005). Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation. J. Virol. 79: 12112-12116 [Abstract] [Full Text]  
  • Roberts, A. D., Ely, K. H., Woodland, D. L. (2005). Differential contributions of central and effector memory T cells to recall responses. JEM 202: 123-133 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»