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Journal of Virology, March 2005, p. 3873-3877, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3873-3877.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Human Cytomegalovirus Immediate-Early 2 Gene Expression Blocks Virus-Induced Beta Interferon Production

R. Travis Taylor{dagger} and Wade A. Bresnahan*

Department of Microbiology, University of Minnesota, Minneapolis, Minnesota

Received 12 August 2004/ Accepted 2 November 2004

The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-ß) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-ß during HCMV infection. IE86 also efficiently blocked the induction of IFN-ß following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-ß is not limited to HCMV infection, identifying IE2 as an IFN-ß antagonist.

* Corresponding author. Mailing address: Department of Microbiology, University of Minnesota, 1060 Mayo Building, MMC196, Minneapolis, MN 55455. Phone: (612) 626-5876. Fax: (612) 626-0623. E-mail: bresn013{at}umn.edu.

{dagger} Present address: Department of Microbiology, UT Southwestern Medical Center, Dallas, TX 75390.

Journal of Virology, March 2005, p. 3873-3877, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3873-3877.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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