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Journal of Virology, December 2005, p. 14992-14997, Vol. 79, No. 23
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.23.14992-14997.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Human Metapneumovirus Induces a Profile of Lung Cytokines Distinct from That of Respiratory Syncytial Virus

Antonieta Guerrero-Plata,1 Antonella Casola,1,2,3 and Roberto P. Garofalo1,2,3*

Departments of Pediatrics,1 Microbiology and Immunology,2 Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 775553

Received 14 July 2005/ Accepted 1 September 2005

Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovirus (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent inducer of granulocyte-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-{alpha}) and IFN-{gamma} responses than RSV. In regard to immunomodulatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.

* Corresponding author. Mailing address: Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0369. Phone: (409) 772-2658. Fax: (409) 772-1761. E-mail: rpgarofa{at}utmb.edu.

Journal of Virology, December 2005, p. 14992-14997, Vol. 79, No. 23
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.23.14992-14997.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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